Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis.

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作者： Jingwen,Xu ^[1] ; Zhenhua,Tian ^[2] ; Zhe,Li ^[3] ; Xiaoshi,Du ^[2] ; Yansong,Cui ^[4] ; Jiangrong,Wang ^[3] ; Mei,Gao ^[5] ; Yinglong,Hou ^[6]

作者单位： Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China; Shandong University of Traditional Chinese Medicine, Jinan, China. ^[1] Shandong University of Traditional Chinese Medicine, Jinan, China. ^[2] Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China. ^[3] Cheeloo College of Medicine, Shandong University, Jinan, China. ^[4] Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China; Shandong University of Traditional Chinese Medicine, Jinan, China. Electronic address: gaomei0217@163.com. ^[5] Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China; Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address: houyinglong2010@hotmail.com. ^[6]

关键词 Atherosclerosis Inflammatory plaque Macrophages Network pharmacology Puerarin and tanshinone IIA (Pue-tan)Succinate/HIF-1α/IL-1β axis

主题词小鼠(Mice);动物(Animals);斑块, 动脉粥样硬化(Plaque, Atherosclerotic);琥珀酸(Succinic Acid);白细胞介素1β(Interleukin-1beta);动脉粥样硬化(Atherosclerosis);琥珀酸盐(Succinates)

DOI 10.1016/j.jep.2023.116675

PMID 37257708

发布时间 2023-08-24

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