IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming.

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作者： Ke,Cheng ^[1] ; Shu,Liu ^[1] ; Cai,Li ^[1] ; Yujun,Zhao ^[1] ; Qiang,Wang ^[2]

作者单位： Department of Transplantation, The Third Xiangya Hospital, Central South University, China; Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, China. ^[1] Department of Transplantation, The Third Xiangya Hospital, Central South University, China; Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, China. Electronic address: wqiang@csu.edu.cn. ^[2]

关键词 Acute-on-chronic liver failure (ACLF)Hepatocyte reprogramming/fetal liver programme Hypoxia-inducible factor (HIF)Insulin-like growth factor-2 RNA-binding protein-3 (IGF2BP3)N6-methyladenosine (m6A) RNA modification Yes-associated protein (YAP)

主题词人类(Humans);肝细胞(Hepatocytes);信号传导(Signal Transduction);RNA, 信使(RNA, Messenger);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit)

DOI 10.1016/j.cellsig.2023.110727

PMID 37257765

发布时间 2023-06-20

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