A DNA phosphorothioation-based Dnd defense system provides resistance against various phages and is compatible with the Ssp defense system.

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作者： Susu,Jiang ^[1] ; Ke,Chen ^[2] ; Yingying,Wang ^[1] ; Yueying,Zhang ^[2] ; Yaru,Tang ^[1] ; Wanqiu,Huang ^[1] ; Xiaolin,Xiong ^[1] ; Shi,Chen ^[1] ; Chao,Chen ^[3] ; Lianrong,Wang ^[1]

作者单位： Department of Gastroenterology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , Wuhan, Hubei, China. ^[1] Department of Respiratory Diseases, The Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University , Zhengzhou, Henan, China. ^[2] Department of Burn and Plastic Surgery, Shenzhen Institute of Translational Medicine, Health Science Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen, Guangdong, China. ^[3]

关键词 DNA methylation DNA phosphorothioation Dnd systems Ssp systems phage resistance restriction-modification systems

主题词细菌噬菌体(Bacteriophages);基因组, 细菌(Genome, Bacterial);细菌(Bacteria);DNA(DNA);DNA甲基化(DNA Methylation)

DOI 10.1128/mbio.00933-23

PMID 37260233

发布时间 2023-10-26

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