Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.

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作者： Xiaotong,Yang ^[1] ; Zhengyan,Zhang ^[1] ; Xuqing,Shen ^[1] ; Junyi,Xu ^[1] ; Yawen,Weng ^[1] ; Wei,Wang ^[2] ; Jing,Xue ^[3]

作者单位： State Key Laboratory of Systems Medicine for Cancer , Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, China. ^[1] Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai, 200080, China. wangwei_0306@163.com. ^[2] State Key Laboratory of Systems Medicine for Cancer , Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, 160 Pujian Rd, Shanghai, 200127, China. jingxue@sjtu.edu.cn. ^[3]

关键词 Butyrate Clostridium butyricum Ferroptosis Intratumoral microbiota PDAC

主题词小鼠(Mice);动物(Animals);人类(Humans);丁酸盐类(Butyrates);酪酸梭状芽胞杆菌(Clostridium butyricum);胰腺肿瘤(Pancreatic Neoplasms);癌, 胰腺管(Carcinoma, Pancreatic Ductal)

DOI 10.1007/s13402-023-00831-8

PMID 37261698

发布时间 2023-12-13

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