Defining function of wild-type and three patient-specific <i>TP53</i> mutations in a zebrafish model of embryonal rhabdomyosarcoma.

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第一作者： Jiangfei,Chen

第一单位： Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou, China.

作者： Jiangfei,Chen ^[1] ; Kunal,Baxi ^[2] ; Amanda E,Lipsitt ^[2] ; Nicole Rae,Hensch ^[3] ; Long,Wang ^[2] ; Prethish,Sreenivas ^[4] ; Paulomi,Modi ^[2] ; Xiang Ru,Zhao ^[3] ; Antoine,Baudin ^[2] ; Daniel G,Robledo ^[3] ; Abhik,Bandyopadhyay ^[2] ; Aaron,Sugalski ^[3] ; Anil K,Challa ^[2] ; Dias,Kurmashev ^[3] ; Andrea R,Gilbert ^[2] ; Gail E,Tomlinson ^[3] ; Peter,Houghton ^[2] ; Yidong,Chen ^[5] ; Madeline N,Hayes ^[2] ; Eleanor Y,Chen ^[2] ; David S,Libich ^[4] ; Myron S,Ignatius ^[2]

作者单位： Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou, China. ^[1] Greehey Children's Cancer Research Institute (GCCRI), UT Health Sciences Center, San Antonio, United States. ^[2] Department of Molecular Medicine, UT Health Sciences Center, San Antonio, United States. ^[3] Department of Pediatrics, Division of Hematology Oncology, UT Health Sciences Center, San Antonio, United States. ^[4] Department of Biochemistry and Structural Biology, UT Health Sciences Center, San Antonio, United States. ^[5] Department of Biology, University of Alabama at Birmingham, Birmingham, United States. ^[6] Department of Pathology and Laboratory Medicine, UT Health Sciences Center, San Antonio, United States. ^[7] Department of Population Health Sciences, UT Health Sciences Center, San Antonio, United States. ^[8] Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada. ^[9] Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States. ^[10]

关键词 TP53 TP53C176F TP53P153Δ TP53Y220C cancer biology mutant tp53 rare varients rhabdomyosarcoma tumor initiation zebrafish

主题词动物(Animals);小脑肿瘤(Cerebellar Neoplasms);突变(Mutation);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));横纹肌肉瘤, 胚胎型(Rhabdomyosarcoma, Embryonal);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);斑马鱼(Zebrafish)

DOI 10.7554/eLife.68221

PMID 37266578

发布时间 2023-11-02

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