Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.

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作者： Masanori,Sawamura ^[1] ; Junichiro,Ohira ^[2] ; Rie,Hikawa ^[2] ; Tomoyuki,Ishimoto ^[2] ; Etsuro,Nakanishi ^[2] ; Hodaka,Yamakado ^[2] ; Ryosuke,Takahashi ^[3]

作者单位： Department of Neurology, Kyoto University Hospital, Kyoto, Japan. Electronic address: masawa@kuhp.kyoto-u.ac.jp. ^[1] Department of Neurology, Kyoto University Hospital, Kyoto, Japan. ^[2] Department of Neurology, Kyoto University Hospital, Kyoto, Japan. Electronic address: ryosuket@kuhp.kyoto-u.ac.jp. ^[3]

关键词 Propagation intranasal administration olfactory mucosa α-synuclein

主题词小鼠(Mice);动物(Animals);Lewy体(Lewy Bodies);嗅球(Olfactory Bulb);投药, 鼻内(Administration, Intranasal);α突触核蛋白(alpha-Synuclein);帕金森病(Parkinson Disease)

DOI 10.1016/j.parkreldis.2023.105440

PMID 37267818

发布时间 2023-11-16

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