Pexidartinib hydrochloride exposure induces developmental toxicity and immunotoxicity in zebrafish embryos via activation of Wnt signaling.

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第一作者： Fasheng,Liu

第一单位： Jiangxi Key Laboratory of Developmental Biology of Organs, Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Health Science Center,Jinggangshan University, Ji'an, 343009, Jiangxi, China.

作者： Fasheng,Liu ^[1] ; Hongmei,Hu ^[2] ; Guilan,Chen ^[1] ; Yanqi,Lin ^[1] ; Wei,Li ^[1] ; Ziyi,Liu ^[1] ; Chao,Chen ^[3] ; Xue,Li ^[3] ; Sujie,Sun ^[3] ; Li,Zhang ^[3] ; Dou,Yang ^[1] ; Kangyu,Liu ^[3] ; Guanghua,Xiong ^[1] ; Xinjun,Liao ^[1] ; Huiqiang,Lu ^[1] ; Zigang,Cao ^[4] ; Jianjun,Chen ^[5]

作者单位： Jiangxi Key Laboratory of Developmental Biology of Organs, Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Health Science Center,Jinggangshan University, Ji'an, 343009, Jiangxi, China. ^[1] Jiangxi Key Laboratory of Developmental Biology of Organs, Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Health Science Center,Jinggangshan University, Ji'an, 343009, Jiangxi, China; Translational Research Institute of Brain and Brain-like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. ^[2] Translational Research Institute of Brain and Brain-like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. ^[3] Jiangxi Key Laboratory of Developmental Biology of Organs, Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Health Science Center,Jinggangshan University, Ji'an, 343009, Jiangxi, China. Electronic address: zigangcao@126.com. ^[4] Translational Research Institute of Brain and Brain-like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. Electronic address: chenjianjun@tongji.edu.cn. ^[5]

关键词 Developmental toxicity Immunotoxicity Pexidartinib Wnt signaling

主题词动物(Animals);斑马鱼(Zebrafish);氨基吡啶类(Aminopyridines);炎症(Inflammation);胚胎, 非哺乳动物(Embryo, Nonmammalian)

DOI 10.1016/j.fsi.2023.108849

PMID 37268155

发布时间 2023-06-13

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准确一般字义偏差语意偏离译文作用小提交