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Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment.

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第一作者： Yifan,Luo

第一单位： Department of Pharmaceutics, School of Pharmacy, Minhang Hospital, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 201203, China.

作者： Yifan,Luo ^[1] ; Chao,Li ^[1] ; Yiwen,Zhang ^[1] ; Peixin,Liu ^[1] ; Hongyi,Chen ^[1] ; Zhenhao,Zhao ^[1] ; Yu,Wang ^[1] ; Zheng,Zhou ^[1] ; Haolin,Song ^[1] ; Boyu,Su ^[1] ; Chufeng,Li ^[1] ; Xuwen,Li ^[1] ; Tongyu,Zhang ^[1] ; Haoyu,You ^[1] ; Yuxing,Wu ^[1] ; Zonghua,Tian ^[1] ; Shilin,Zhang ^[1] ; Yun,Guo ^[1] ; Hongrui,Fan ^[1] ; Qinjun,Chen ^[1] ; Chen,Jiang ^[2] ; Tao,Sun ^[3]

作者单位： Department of Pharmaceutics, School of Pharmacy, Minhang Hospital, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 201203, China. ^[1] Department of Pharmaceutics, School of Pharmacy, Minhang Hospital, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 201203, China. Electronic address: jiangchen@shmu.edu.cn. ^[2] Department of Pharmaceutics, School of Pharmacy, Minhang Hospital, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 201203, China. Electronic address: sunt@fudan.edu.cn. ^[3]

关键词 Gemcitabine Nitroimidazole Pancreatic cancer Penetration Tumor hypoxia

主题词人类(Humans);微胶粒(Micelles);肿瘤微环境(Tumor Microenvironment);胰腺肿瘤(Pancreatic Neoplasms);癌, 胰腺管(Carcinoma, Pancreatic Ductal);谷胱甘肽(Glutathione);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1016/j.actbio.2023.05.047

PMID 37276955

发布时间 2024-01-02

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