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Prognostic and predictive value of metformin in the European Organisation for Research and Treatment of Cancer 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma.

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第一作者: Oliver John,Kennedy
第一单位: University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom; Christie NHS Foundation Trust, Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom. Electronic address: ojk@doctors.org.uk.
作者单位: University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom; Christie NHS Foundation Trust, Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom. Electronic address: ojk@doctors.org.uk. [1] EORTC Headquarters, Brussels, Belgium. [2] Division of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom. [3] Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy. [4] Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands. [5] Melanoma Institute Australia, the University of Sydney, and Mater and Royal North Shore Hospitals, Sydney, NSW, Australia. [6] Princess Alexandra Hospital, Brisbane, QLD, Australia. [7] Hospices Civils de Lyon Cancer Institute, Lyon, France. [8] Alfred Hospital, Melbourne, VIC, Australia. [9] NN Blokhin Cancer Research Center, Moscow, Russian Federation. [10] Fiona Stanley Hospital & Edith Cowan University, Perth, WA, Australia. [11] Westmead and Blacktown Hospitals, Melanoma Institute Australia and the University of Sydney, Sydney, NSW, Australia. [12] Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. [13] Royal Marsden Hospital, London, United Kingdom. [14] Hospital Clinic de Barcelona, Universitat de Barcelona, IDIBAPS, and Spain &Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain. [15] Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. [16] Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. [17] University Hospital Essen, Essen, German Cancer Consortium, Partner Site Essen & University Alliance Ruhr Research Center One Health, Essen, Germany. [18] Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands. [19] Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy. [20] Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands. [21] Aix Marseille University, Hôpital de la Timone, Marseille, France. [22] Department of Dermatology, Johannes Wesling Medical Center, Ruhr University Bochum Campus Minden, Minden, Germany. [23] Centre Hospitalier de l'Université de Montréal (CHUM), Centre de recherche du CHUM, Montreal, QC, Canada. [24] Melanoma Institute Australia, University of Sydney, Sydney, NSW, Australia. [25] Gustave Roussy and Paris-Saclay University, Villejuif, France. [26] Princess Máxima Center and University Medical Center Utrecht, 3584 CS Utrecht, the Netherlands; Comprehensive Cancer Center Munich, Technical University Munich & Ludwig Maximiliaan University, Munich, Germany. [27] Christie NHS Foundation Trust, Manchester, Wilmslow Rd, Manchester M20 4BX, United Kingdom; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. [28] University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy. [29]
DOI 10.1016/j.ejca.2023.04.016
PMID 37277264
发布时间 2023-12-13
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European journal of cancer (Oxford, England : 1990)

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