Hypomethylation and Overexpression of Th17-Associated Genes is a Hallmark of Intestinal CD4+ Lymphocytes in Crohn's Disease.

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作者： Zhifu,Sun ^[1] ; Manuel B,Braga-Neto ^[2] ; Yuning,Xiong ^[2] ; Adytia V,Bhagwate ^[1] ; Hunter R,Gibbons ^[2] ; Mary R,Sagstetter ^[2] ; Feda H,Hamdan ^[2] ; Saurabh,Baheti ^[1] ; Jessica,Friton ^[2] ; Asha,Nair ^[1] ; Zhenqing,Ye ^[3] ; William A,Faubion ^[2]

作者单位： Division of Computational Biology, Mayo Clinic, Rochester, MN 55905, USA. ^[1] Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. ^[2] Greehey Children's Cancer Research Institute, UT Health Science Center San Antonio, San Antonio, TX 78229, USA. ^[3]

关键词 C4+ lymphocytes CTCF Crohn’s disease DNA methylation Th17 cells

主题词人类(Humans);DNA甲基化(DNA Methylation);Crohn病(Crohn Disease);Th17细胞(Th17 Cells);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);染色质(Chromatin)

DOI 10.1093/ecco-jcc/jjad093

PMID 37280154

发布时间 2024-06-07

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