Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin.

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作者： Tom S,Chan ^[1] ; Alexander J,Byer-Alcorace ^[2] ; Bachir,Latli ^[3] ; Pingrong,Liu ^[2] ; Hlaing H,Maw ^[2] ; Klairynne G,Raymond ^[2] ; Young-Sun,Scaringella ^[4] ; Aaron M,Teitelbaum ^[5] ; Ting,Wang ^[2] ; Andrea,Whitcher-Johnstone ^[2] ; Mitchell E,Taub ^[6]

作者单位： Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. tom.chan@boehringer-ingelheim.com. ^[1] Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. ^[2] Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. ^[3] Department of Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. ^[4] Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany. ^[5] DMPK Oncology, AstraZeneca Inc., 35 Gatehouse Dr., Waltham, MA, 02451, USA. ^[6]

关键词 human ADME iclepertin metabolism metabolite identification schizophrenia

主题词人类(Humans);色谱法, 液相(Chromatography, Liquid);半衰期(Half-Life);串联质谱法(Tandem Mass Spectrometry);酶抑制剂(Enzyme Inhibitors);代谢网络和途径(Metabolic Networks and Pathways);微粒体, 肝(Microsomes, Liver)

DOI 10.1007/s11095-023-03530-z

PMID 37280472

发布时间 2023-08-24

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