Development and validation of LC-MS/MS methods for the quantification of 101BHG-D01, a novel, long-acting and selective muscarinic receptor antagonist, and its main metabolite M6 in human plasma, urine and feces: Application to a clinical study in healthy Chinese subjects.

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作者： Huaye,Gao ^[1] ; Minlu,Cheng ^[2] ; Haijun,Liu ^[2] ; Li,Ding ^[3]

作者单位： Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211100, China. ^[1] Nanjing Clinical Tech. Laboratories Inc., Nanjing 211100, China. ^[2] Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211100, China. Electronic address: dingli@cpu.edu.cn. ^[3]

关键词 101BHG-D01 LC-MS/MS Long-acting muscarinic antagonist Metabolite M6 Pharmacokinetics

主题词人类(Humans);色谱法, 液相(Chromatography, Liquid);串联质谱法(Tandem Mass Spectrometry);粪便(Feces);受体, 毒蕈碱(Receptors, Muscarinic);结果可重复性(Reproducibility of Results);色谱法, 高压液相(Chromatography, High Pressure Liquid)

DOI 10.1016/j.jpba.2023.115498

PMID 37285657

发布时间 2023-06-12

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