首页> Nature communications> Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

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第一作者： Xinhong,Chen

第一单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

作者： Xinhong,Chen ^[1] ; Damien A,Wolfe ^[1] ; Dhanesh Sivadasan,Bindu ^[2] ; Mengying,Zhang ^[1] ; Naz,Taskin ^[3] ; David,Goertsen ^[1] ; Timothy F,Shay ^[1] ; Erin E,Sullivan ^[1] ; Sheng-Fu,Huang ^[4] ; Sripriya,Ravindra Kumar ^[1] ; Cynthia M,Arokiaraj ^[1] ; Viktor M,Plattner ^[5] ; Lillian J,Campos ^[6] ; John K,Mich ^[3] ; Deja,Monet ^[3] ; Victoria,Ngo ^[7] ; Xiaozhe,Ding ^[1] ; Victoria,Omstead ^[3] ; Natalie,Weed ^[3] ; Yeme,Bishaw ^[3] ; Bryan B,Gore ^[3] ; Ed S,Lein ^[3] ; Athena,Akrami ^[5] ; Cory,Miller ^[7] ; Boaz P,Levi ^[3] ; Annika,Keller ^[8] ; Jonathan T,Ting ^[9] ; Andrew S,Fox ^[6] ; Cagla,Eroglu ^[2] ; Viviana,Gradinaru ^[10]

作者单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. ^[1] Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA. ^[2] Allen Institute for Brain Science, Seattle, WA, USA. ^[3] Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland. ^[4] Sainsbury Wellcome Centre, University College London, London, UK. ^[5] Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA. ^[6] Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA. ^[7] Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland.;Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zürich, Switzerland. ^[8] Allen Institute for Brain Science, Seattle, WA, USA.;Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA. ^[9] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. viviana@caltech.edu. ^[10]