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Network pharmacology-based approach uncovers the pharmacodynamic components and mechanism of Fructus Tribuli for improving endothelial dysfunction in hypertension.

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第一作者： Shu-Yue,Wang

第一单位： School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Binzhou Hospital of Traditional Chinese Medicine, Binzhou, 256600, China.

作者： Shu-Yue,Wang ^[1] ; Xiao-Chen,Sun ^[2] ; Xi-Yu,Lv ^[3] ; Jing-Na,Li ^[3] ; Bing,Han ^[3] ; Kun-Lin,Liu ^[3] ; Shuai,Wang ^[3] ; Hua-Gang,Sheng ^[3] ; Chao,Zhang ^[4] ; Fei,Guo ^[5] ; Yi-Dong,Cui ^[6]

作者单位： School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Binzhou Hospital of Traditional Chinese Medicine, Binzhou, 256600, China. ^[1] School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Zaozhuang Vocational College of Science & Technology, Zaozhuang, 277500, China. ^[2] School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. ^[3] School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: tougaotcm@163.com. ^[4] The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, China. Electronic address: wenxianjiansuotcm@126.com. ^[5] Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012, China. Electronic address: yidongcui@qq.com. ^[6]

关键词 Endothelial dysfunction Fructus Tribuli Network pharmacology PI3K/AKT/eNOS signaling pathway

医学主题词动物(Animals);大鼠(Rats);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);高血压(Hypertension);中草药(Drugs, Chinese Herbal)

DOI 10.1016/j.jep.2023.116749

PMID 37295575

发布时间 2023-06-19

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