首页> International journal of molecular sciences> Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages.

Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages.

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第一作者： Ittai B,Muller

第一单位： Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.

作者： Ittai B,Muller ^[1] ; Marry,Lin ^[1] ; Robert,de Jonge ^[1] ; Nico,Will ^[2] ; Baltasar,López-Navarro ^[3] ; Conny,van der Laken ^[4] ; Eduard A,Struys ^[1] ; Cees B M,Oudejans ^[1] ; Yehuda G,Assaraf ^[5] ; Jacqueline,Cloos ^[6] ; Amaya,Puig-Kröger ^[3] ; Gerrit,Jansen ^[4]

作者单位： Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands. ^[1] Facility for Environment and Natural Science, Brandenburg Technical University Cottbus-Senftenberg, 01968 Senftenberg, Germany. ^[2] Laboratorio de Inmuno-Metabolismo e Inflamación, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital Gregorio Marañón, 28007 Madrid, Spain. ^[3] Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Center-location VUmc, 1081 HV Amsterdam, The Netherlands. ^[4] The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel. ^[5] Department of Hematology, Amsterdam University Medical Center-location VUmc, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands. ^[6]

关键词 alternative splicing folate metabolism folylpolyglutamate synthetase gene expression macrophages methotrexate