Design, synthesis and antitubercular activity of novel N-(amino)piperazinyl benzothiazinones with improved safety.

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作者： Apeng,Wang ^[1] ; Na,Du ^[1] ; Huijuan,Song ^[1] ; Yuehao,Zhang ^[2] ; Xijun,Zhong ^[1] ; Jizhou,Wu ^[1] ; Tiezheng,Xue ^[2] ; Mingliang,Liu ^[3] ; Bin,Wang ^[4] ; Kai,Lv ^[5] ; Yu,Lu ^[6]

作者单位： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. ^[1] Hebei Medical University, Shijiazhuang, 050017, China. ^[2] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lmllyx@126.com. ^[3] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital College of Pharmacy, Medical University, Beijing, 100149, China. ^[4] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lvkailk@hotmail.com. ^[5] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital College of Pharmacy, Medical University, Beijing, 100149, China. Electronic address: luyu4876@hotmail.com. ^[6]

关键词 Acute toxicity Antitubercular activity Benzothiazinones N-(amino)piperazine Synthesis