β-Turn editing in Gramicidin S: Activity impact on replacing proline α-carbon with stereodynamic nitrogen.

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作者： Jhajan,Lal ^[1] ; Grace,Kaul ^[2] ; Abdul,Akhir ^[3] ; Deepanshi,Saxena ^[3] ; Harshita,Dubkara ^[1] ; Shashank,Shekhar ^[1] ; Sidharth,Chopra ^[4] ; Damodara N,Reddy ^[5]

作者单位： Division of Medicinal and Process Chemistry, CSIR-CDRI, Lucknow 226031, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, UP 201002, India. ^[1] Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, UP 201002, India. ^[2] Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow 226031, India. ^[3] Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, UP 201002, India. Electronic address: siddharth.chopra@cdri.res.in. ^[4] Division of Medicinal and Process Chemistry, CSIR-CDRI, Lucknow 226031, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, UP 201002, India. Electronic address: damodara.reddy@cdri.res.in. ^[5]

关键词 Antimicrobial peptides Azaproline Gramicidin S MDR S. aureus Proline editing