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MALDI-ISD mass spectrometry analysis as a simple and reliable tool to detect post-translational modifications of hemoglobin variants: the case of Hb Raleigh.

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第一作者： Selene,De Benedittis

第一单位： National Research Council, Institute for Biomedical Research and Innovation (IRIB), Cosenza , Italy.;Department of Medical and Surgical Sciences, University "Magna Graecia ", Germaneto, Catanzaro, Italy.

作者： Selene,De Benedittis ^[1] ; Patrizia,Spadafora ^[2] ; Marco,Gaspari ^[3] ; Gabriele,Qualtieri ^[4] ; Olivier,Gallo ^[2] ; Gemma,Di Palma ^[2] ; Francesca,Cavalcanti ^[2] ; Luigi,Citrigno ^[2] ; Antonio,Qualtieri ^[2]

作者单位： National Research Council, Institute for Biomedical Research and Innovation (IRIB), Cosenza , Italy.;Department of Medical and Surgical Sciences, University "Magna Graecia ", Germaneto, Catanzaro, Italy. ^[1] National Research Council, Institute for Biomedical Research and Innovation (IRIB), Cosenza , Italy. ^[2] Research Centre for Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy. ^[3] U.O.C Hematology, Annunziata Hospital, Cosenza, Italy. ^[4]

关键词 hemoglobin variant in-source decay mass spectrometry post-translational modification

医学主题词人类(Humans);光谱法, 质量, 基质辅助激光解吸电离(Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization);血红蛋白类, 异常(Hemoglobins, Abnormal);氨基酸序列(Amino Acid Sequence);蛋白质加工, 转译后(Protein Processing, Post-Translational)

DOI 10.1515/cclm-2023-0442

PMID 37307396

发布时间 2023-11-12

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