In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.

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第一作者： Pedro P G,Guimarães

第一单位： Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.

作者： Pedro P G,Guimarães ^[1] ; Christian G,Figueroa-Espada ^[2] ; Rachel S,Riley ^[1] ; Ningqiang,Gong ^[1] ; Lulu,Xue ^[3] ; Tomasz,Sewastianik ^[1] ; Peter S,Dennis ^[1] ; Claudia,Loebel ^[4] ; Amanda,Chung ^[5] ; Sarah J,Shepherd ^[4] ; Rebecca M,Haley ^[6] ; Alex G,Hamilton ^[7] ; Rakan,El-Mayta ^[1] ; Karin,Wang ^[1] ; Robert,Langer ^[1] ; Daniel G,Anderson ^[1] ; Ruben D,Carrasco ^[8] ; Michael J,Mitchell ^[7]

作者单位： Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104. ^[1] Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. ^[2] Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028. ^[3] Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215. ^[4] Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw 02776, Poland. ^[5] Department of Materials Science & Engineering, University of Michigan, North Campus Research Complex, Ann Arbor, MI 48109. ^[6] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142. ^[7] Department of Bioengineering, Temple University, Philadelphia, PA 19122. ^[8] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142. ^[9] Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142. ^[10] Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142. ^[11] Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115. ^[12] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. ^[13] Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. ^[14] Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. ^[15] Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. ^[16]

关键词 RNA therapeutics drug delivery nanomedicine