RELA governs a network of islet-specific metabolic genes necessary for beta cell function.

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作者： Nathan W,Zammit ^[1] ; Ying Ying,Wong ^[2] ; Stacey N,Walters ^[3] ; Joanna,Warren ^[4] ; Simon C,Barry ^[5] ; Shane T,Grey ^[1]

作者单位： Transplantation Immunology Laboratory, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. ^[1] Translation Science Pillar, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. ^[2] Department of Immunology, Harvard Medical School, Boston, MA, USA. ^[3] Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. ^[4] Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia. ^[5] Transplantation Immunology Laboratory, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. s.grey@garvan.org.au. ^[6] Translation Science Pillar, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. s.grey@garvan.org.au. ^[7] School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia. s.grey@garvan.org.au. ^[8]

关键词 Beta cells Diabetes Enhancer hubs Glucocorticoids Islets Metabolism NEMO NF-κB TNFAIP3 p65