首页> Cancer research and treatment> Long-term Complete Remission of Decitabine-Primed Tandem CD19/CD22 CAR-T Therapy with PD-1 and BTK Inhibitors Maintenance in a Refractory Primary Central Nervous System Lymphoma Patient.

Long-term Complete Remission of Decitabine-Primed Tandem CD19/CD22 CAR-T Therapy with PD-1 and BTK Inhibitors Maintenance in a Refractory Primary Central Nervous System Lymphoma Patient.

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第一作者： Rui,Zou

第一单位： College of Pharmaceutical Sciences Soochow University, The First Affiliated Hospital of Soochow University, Suzhou, China.;National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.;Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.

作者： Rui,Zou ^[1] ; Xiao,Zhou ^[2] ; Hailing,Liu ^[3] ; Peng,Wang ^[4] ; Fan,Xia ^[5] ; Liqing,Kang ^[6] ; Lei,Yu ^[6] ; Depei,Wu ^[4] ; Zhengming,Jin ^[4] ; Changju,Qu ^[4]

作者单位： College of Pharmaceutical Sciences Soochow University, The First Affiliated Hospital of Soochow University, Suzhou, China.;National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.;Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. ^[1] Department Of Hematology & Oncology, Wuxi Taihu Lake Hospital, Wuxi, China. ^[2] Department of Radiology, People's Hospital of Binhai County, Yancheng, China. ^[3] National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.;Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. ^[4] Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, China. ^[5] School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.;Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd., Shanghai, China. ^[6]

关键词 CD19/CD22 Chimeric antigen receptor T-cell therapy Decitabine Diffuse Large B-Cell Lymphoma Primary central nervous system lymphoma

医学主题词人类(Humans);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);脑(Brain);中枢神经系统肿瘤(Central Nervous System Neoplasms);淋巴瘤, 非霍奇金(Lymphoma, Non-Hodgkin)

DOI 10.4143/crt.2023.371

PMID 37321275

发布时间 2023-12-13

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