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Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.

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第一作者： Kou,Nishikubo

第一单位： Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

作者： Kou,Nishikubo ^[1] ; Ryuichi,Ohgaki ^[2] ; Xingming,Liu ^[1] ; Hiroki,Okanishi ^[1] ; Minhui,Xu ^[1] ; Hitoshi,Endou ^[3] ; Yoshikatsu,Kanai ^[4]

作者单位： Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ^[1] Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ohgaki@pharma1.med.osaka-u.ac.jp.;Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan. ohgaki@pharma1.med.osaka-u.ac.jp. ^[2] J-Pharma Co., Ltd., Yokohama, Japan. ^[3] Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ykanai@pharma1.med.osaka-u.ac.jp.;Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan. ykanai@pharma1.med.osaka-u.ac.jp. ^[4]

关键词 Amino acid transporter Cancer chemotherapy Combination therapy Cytotoxic anticancer drugs Essential amino acids Gemcitabine LAT1 Large neutral amino acids Molecularly targeted drugs SLC7A5

DOI 10.1186/s12935-023-02957-z

PMID 37322479

发布时间 2023-06-19

基金项目

22J14119/Japan Society for the Promotion of Science 18K06931/Japan Society for the Promotion of Science 19H03407/Japan Society for the Promotion of Science JP19cm0106151/Japan Agency for Medical Research and Development 12-02/National Institutes of Biomedical Innovation, Health and Nutrition H25B7/Ministry of Education, Culture, Sports, Science and Technology

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准确一般字义偏差语意偏离译文作用小提交