Novel antimicrobial peptide DvAMP serves as a promising antifungal agent against Cryptococcus neoformans.

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第一作者： Longbing,Yang

第一单位： The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China; Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, China.

作者： Longbing,Yang ^[1] ; Zhuqing,Tian ^[2] ; Wenjing,Zhao ^[2] ; Jin,Zhang ^[3] ; Chunren,Tian ^[2] ; Luoxiong,Zhou ^[4] ; Zhenlong,Jiao ^[5] ; Jian,Peng ^[6] ; Guo,Guo ^[7]

作者单位： The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China; Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, China. ^[1] The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China. ^[2] School of Public Health, Guizhou Medical University, Guiyang 550025, China. ^[3] The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; School of Public Health, Guizhou Medical University, Guiyang 550025, China. ^[4] The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, China. ^[5] The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China. ^[6] The Key and Characteristic Laboratory of Modern Pathogen Biology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China; Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, China. Electronic address: guoguo@gmc.edu.cn. ^[7]

关键词 Antimicrobial peptide Cryptococcus neoformans DvAMP Galleria mellonella Membrane disruption Mitochondrial dysfunction

主题词动物(Animals);人类(Humans);抗真菌药(Antifungal Agents);隐球菌病(Cryptococcosis);新型隐球菌(Cryptococcus neoformans);微生物敏感性试验(Microbial Sensitivity Tests);蛾(Moths)

DOI 10.1016/j.bioorg.2023.106679

PMID 37329812

发布时间 2024-01-16

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