Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG.

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作者： Gergely Tibor,Kozma ^[1] ; Tamás,Mészáros ^[1] ; Petra,Berényi ^[1] ; Réka,Facskó ^[1] ; Zsófia,Patkó ^[2] ; Csaba Zs,Oláh ^[3] ; Adrienne,Nagy ^[4] ; Tamás Gyula,Fülöp ^[5] ; Kathryn Anne,Glatter ^[6] ; Tamás,Radovits ^[7] ; Béla,Merkely ^[7] ; János,Szebeni ^[8]

作者单位： Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University, Budapest, Hungary; SeroScience LLC, Budapest, Hungary. ^[1] Department of Radiology, BAZ County Central Hospital and Borsod County University Teaching Hospital and Miskolc University, Miskolc, Hungary. ^[2] Department of Neurosurgery, BAZ County Central Hospital and Borsod County University Teaching Hospital, Miskolc, Hungary. ^[3] Department of Allergy, Heim Pál Children's Hospital, Budapest, Hungary. ^[4] TECOdevelopment GmbH, Rheinbach, Germany. ^[5] Gratz College, Philadelphia, PA, USA. ^[6] Heart and Vascular Center, Semmelweis University, Budapest, Hungary. ^[7] Nanomedicine Research and Education Center, Department of Translational Medicine, Semmelweis University, Budapest, Hungary; SeroScience LLC, Budapest, Hungary; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health Sciences, Miskolc University, Miskolc, Hungary; Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address: szebeni.janos@med.semmelweis-univ.hu. ^[8]

关键词 Allergy Anaphylaxis Anti-PEG IgG Complement Covid-19 ELISA Hypersensitivity reactions IgM Neutralizing antibodies SARS-CoV-2 Spike protein mRNA

主题词人类(Humans);过敏反应(Anaphylaxis);二醇类(Glycols);免疫球蛋白G(Immunoglobulin G);免疫球蛋白M(Immunoglobulin M);RNA, 信使(RNA, Messenger)

DOI 10.1016/j.vaccine.2023.06.009

PMID 37330369

发布时间 2024-09-19

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