Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure-Activity Relationship, ADMET, and Molecular Docking Studies.

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作者： Arif,Ali ^[1] ; Muhammad Ishaq Ali,Shah ^[1] ; Chaoping,Fu ^[2] ; Zubair,Hussain ^[3] ; Muhammad Nasimullah,Qureshi ^[4] ; Saira,Farman ^[5] ; Zahida,Parveen ^[5] ; Amir,Zada ^[1] ; Saira,Nayab ^[6] ; Perveen,Fazil ^[7] ; Muhammad,Ateeq ^[1] ; Gauhar,Rehman ^[8] ; Mohammad,Naeem ^[1] ; Mohammad,Ibrahim ^[1] ; Momin,Khan ^[1] ; Waliullah,Khan ^[1]

作者单位： Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Khyber Pakhtunkhwa, Pakistan. ^[1] Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China. ^[2] National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences, Faisalabad 44000, Pakistan. ^[3] Department of Chemistry, University of Swabi, Anbar, Swabi 23561, Khyber Pakhtunkhwa, Pakistan. ^[4] Department of Biochemistry, Abdul Wali Khan University, Mardan 23200, Pakistan. ^[5] Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal 18050, Upper Dir, Khyber Pakhtunkhwa,Pakistan. ^[6] Department of Chemistry, University of Karachi, Karachi 75270, Pakistan. ^[7] Department of Zoology, Abdul Wali Khan University, Mardan 23200, Khyber Pakhtunkhwa, Pakistan. ^[8]

DOI 10.1021/acsomega.3c00529

PMID 37332823

发布时间 2023-06-20

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ACS omega

2023年8卷23期

20412-20422页

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Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure-Activity Relationship, ADMET, and Molecular Docking Studies.

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Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure-Activity Relationship, ADMET, and Molecular Docking Studies.

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