Single cell transcriptomic analysis of Graves' disease thyroid glands reveals the broad immunoregulatory potential of thyroid follicular and stromal cells and implies a major re-interpretation of the role of aberrant HLA class II expression in autoimmunity.

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作者： Daniel,Álvarez-Sierra ^[1] ; Jorge,Rodríguez-Grande ^[2] ; Aroa,Gómez-Brey ^[3] ; Irene,Bello ^[4] ; Enric,Caubet ^[5] ; Óscar,González ^[5] ; Carles,Zafón ^[6] ; Carmela,Iglesias ^[7] ; Pablo,Moreno ^[8] ; Núria,Ruiz ^[9] ; Ana,Marín-Sánchez ^[10] ; Roger,Colobran ^[10] ; Ricardo,Pujol-Borrell ^[11]

作者单位： Translational Immunology Research Group, Vall D'Hebron Institute of Research (VHIR), Campus Vall D'Hebron, Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain; Immunology Division, Hospital Universitari Vall D'Hebron (HUVH), Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. Electronic address: danielalsie@gmail.com. ^[1] Microbiology Division, Hospital Universitario Marqués de Valdecilla - IDIVAL, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[2] Transplant Coordination Department, Hospital Universitari Vall D'Hebron (HUVH), Campus Vall D'Hebron. Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[3] Thoracic Surgery and Lung Transplantation Department, Hospital Universitari Vall D'Hebron (HUVH), Barcelona, Campus Vall D'Hebron, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[4] Department of General Surgery, Endocrine Surgery Division, Hospital Universitari Vall D'Hebron (HUVH), Campus Vall D'Hebron, Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[5] Department of Endocrinology and Nutrition, Hospital Universitari Vall D'Hebron (HUVH), Campus Vall D'Hebron, Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[6] Department of Histopathology, Hospital Universitari Vall D'Hebron (HUVH), Campus Vall D'Hebron Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[7] Department of General Surgery, Endocrine Surgery Division, Hospital Universitari de Bellvitge (HUB), Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[8] Department of Histopathology, Hospital Universitari de Bellvitge (HUB), Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[9] Translational Immunology Research Group, Vall D'Hebron Institute of Research (VHIR), Campus Vall D'Hebron, Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain; Immunology Division, Hospital Universitari Vall D'Hebron (HUVH), Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain. ^[10] Translational Immunology Research Group, Vall D'Hebron Institute of Research (VHIR), Campus Vall D'Hebron, Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain; Immunology Division, Hospital Universitari Vall D'Hebron (HUVH), Barcelona, Passeig Vall D'Hebron 119-129, 08035, Spain; Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UAB), Campus Vall D'Hebron, Barcelona, Hospital Universitari Vall D'Hebron and the Other Institutions in the Campus Vall D'Hebron Is, Passeig Vall D'Hebron 119-129, 08035, Spain; Vall d'Hebron Institute of Oncology (VHIO), Centre Cellex, C/ Natzaret, 115-117, 08035 Barcelona, Spain. ^[11]

关键词 Adaptative immunity Peripheral tolerance Thyroid autoimmunity

主题词人类(Humans);自身免疫(Autoimmunity);格雷夫斯病(Graves Disease);细胞黏附分子(Cell Adhesion Molecules)

DOI 10.1016/j.jaut.2023.103072

PMID 37336012

发布时间 2023-08-23

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