PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA.

导出 OA

翻译打印收藏纠错

第一作者： Yingying,Xu

第一单位： School of Pharmacy, Fujian Medical University, Fuzhou, China.

作者： Yingying,Xu ^[1] ; Yijing,Zheng ^[2] ; Xuqiu,Ding ^[1] ; Chengyan,Wang ^[3] ; Bin,Hua ^[4] ; Shilian,Hong ^[1] ; Xiaoman,Huang ^[1] ; Jiali,Lin ^[1] ; Peng,Zhang ^[1] ; Wei,Chen ^[5]

作者单位： School of Pharmacy, Fujian Medical University, Fuzhou, China. ^[1] State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China. ^[2] School of Clinical Medicine, Fujian Medical University, Fuzhou, China. ^[3] Institute of Laboratory Animal Center, Fujian Medical University, Fuzhou, China. ^[4] Department of Pharmacy, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen, China. ^[5] Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, China. ^[6]

关键词 PEGylated peptide gene vector Pulmonary mRNA delivery inhalation safety nano self-assemblies pH-responsive peptide

主题词动物(Animals);小鼠(Mice);RNA, 信使(RNA, Messenger);聚乙烯二醇类(Polyethylene Glycols);肽类(Peptides);转染(Transfection);氢离子浓度(Hydrogen-Ion Concentration)

DOI 10.1080/10717544.2023.2219870

PMID 37336779

发布时间 2023-07-01

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交