A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression.

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作者： Lauren E,Davey ^[1] ; Per N,Malkus ^[2] ; Max,Villa ^[3] ; Lee,Dolat ^[4] ; Zachary C,Holmes ^[5] ; Jeff,Letourneau ^[4] ; Eduard,Ansaldo ^[5] ; Lawrence A,David ^[4] ; Gregory M,Barton ^[5] ; Raphael H,Valdivia ^[4]

作者单位： Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. laurendavey@uvic.ca. ^[1] Duke Microbiome Center, Duke University, Durham, NC, USA. laurendavey@uvic.ca. ^[2] Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada. laurendavey@uvic.ca. ^[3] Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. ^[4] Duke Microbiome Center, Duke University, Durham, NC, USA. ^[5] Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. ^[6] Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. raphael.valdivia@duke.edu. ^[7] Duke Microbiome Center, Duke University, Durham, NC, USA. raphael.valdivia@duke.edu. ^[8]

主题词动物(Animals);小鼠(Mice);黏蛋白类(Mucins);甾醇类(Sterols);肠(Intestines);无特异性病原体有机物(Specific Pathogen-Free Organisms);DNA转座子(DNA Transposable Elements);诱变(Mutagenesis);细胞内间隙(Intracellular Space);细菌蛋白质类(Bacterial Proteins);转录, 遗传(Transcription, Genetic)

DOI 10.1038/s41564-023-01407-w

PMID 37337046

发布时间 2024-03-15

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Nature microbiology

2023年8卷8期

1450-1467页

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A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression.

Nature microbiology

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A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression.

Nature microbiology

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Nature microbiology

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