Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride.

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第一作者： Annette E,Dodge

第一单位： Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.;Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.

作者： Annette E,Dodge ^[1] ; Danielle P M,LeBlanc ^[2] ; Gu,Zhou ^[2] ; Andrew,Williams ^[2] ; Matthew J,Meier ^[2] ; Phu,Van ^[3] ; Fang Yin,Lo ^[3] ; Charles C,Valentine Iii ^[3] ; Jesse J,Salk ^[3] ; Carole L,Yauk ^[4] ; Francesco,Marchetti ^[5]

作者单位： Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.;Department of Biology, University of Ottawa, Ottawa, Ontario, Canada. ^[1] Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada. ^[2] TwinStrand Biosciences Inc., Seattle, Washington, USA. ^[3] Department of Biology, University of Ottawa, Ottawa, Ontario, Canada. carole.yauk@uottawa.ca.;Department of Biology, Carleton University, Ottawa, Ontario, Canada. carole.yauk@uottawa.ca. ^[4] Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada. francesco.marchetti@hc-sc.gc.ca.;Department of Biology, Carleton University, Ottawa, Ontario, Canada. francesco.marchetti@hc-sc.gc.ca. ^[5]

关键词 Duplex sequencing Error-corrected sequencing Genetic toxicology Mutagenesis Transgenic rodent assay ecNGS