Optimizing the Cell Painting assay for image-based profiling.

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第一作者： Beth A,Cimini

第一单位： Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

作者： Beth A,Cimini ^[1] ; Srinivas Niranj,Chandrasekaran ^[1] ; Maria,Kost-Alimova ^[2] ; Lisa,Miller ^[2] ; Amy,Goodale ^[3] ; Briana,Fritchman ^[3] ; Patrick,Byrne ^[2] ; Sakshi,Garg ^[4] ; Nasim,Jamali ^[1] ; David J,Logan ^[5] ; John B,Concannon ^[6] ; Charles-Hugues,Lardeau ^[7] ; Elizabeth,Mouchet ^[8] ; Shantanu,Singh ^[1] ; Hamdah,Shafqat Abbasi ^[1] ; Peter,Aspesi ^[6] ; Justin D,Boyd ^[5] ; Tamara,Gilbert ^[5] ; David,Gnutt ^[9] ; Santosh,Hariharan ^[10] ; Desiree,Hernandez ^[3] ; Gisela,Hormel ^[4] ; Karolina,Juhani ^[8] ; Michelle,Melanson ^[2] ; Lewis H,Mervin ^[8] ; Tiziana,Monteverde ^[8] ; James E,Pilling ^[8] ; Adam,Skepner ^[2] ; Susanne E,Swalley ^[11] ; Anita,Vrcic ^[2] ; Erin,Weisbart ^[1] ; Guy,Williams ^[8] ; Shan,Yu ^[12] ; Bolek,Zapiec ^[4] ; Anne E,Carpenter ^[13]

作者单位： Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[1] Center for Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[2] Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[3] Merck Healthcare KGaA, Darmstadt, Germany. ^[4] Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA. ^[5] Chemical Biology & Therapeutics Department, Novartis Institutes for Biomedical Research, Cambridge, MA, USA. ^[6] Janssen Pharmaceutica N.V., Beerse, Belgium. ^[7] AstraZeneca BioPharmaceuticals R&D, Cambridge, UK. ^[8] Bayer AG, Research & Development, Pharmaceuticals, Wuppertal, Germany. ^[9] Discovery Sciences, Pfizer, Groton, CT, USA. ^[10] Biogen, Inc., Cambridge, MA, USA. ^[11] Takeda Development Center Americas, Inc., San Diego, CA, USA. ^[12] Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. anne@broadinstitute.org. ^[13]

主题词图像处理, 计算机辅助(Image Processing, Computer-Assisted);显微镜检查, 荧光(Microscopy, Fluorescence);细胞培养技术(Cell Culture Techniques);线粒体(Mitochondria);软件(Software)

DOI 10.1038/s41596-023-00840-9

PMID 37344608

发布时间 2024-09-26

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