Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model.

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作者： Mehdi,Nikfar ^[1] ; Haoyang,Mi ^[1] ; Chang,Gong ^[2] ; Holly,Kimko ^[3] ; Aleksander S,Popel ^[1]

作者单位： Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. ^[1] Clinical Pharmacology & Quantitative Pharmacology, AstraZeneca, Waltham, MA 02451, USA. ^[2] Clinical Pharmacology & Quantitative Pharmacology, AstraZeneca, Gaithersburg, MD 20878, USA. ^[3] Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University, Baltimore, MD 21231, USA. ^[4]

关键词 agent-based Model (ABM)computational digital pathology immune checkpoint inhibitor immunoarchitecture intratumoral heterogeneity quantitative systems pharmacology (QSP)

DOI 10.3390/cancers15102750

PMID 37345087

发布时间 2023-07-01

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