Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer.

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作者： Shota,Shimizu ^[1] ; Jumpei,Kondo ^[2] ; Kunishige,Onuma ^[1] ; Roberto,Coppo ^[3] ; Kasumi,Ota ^[4] ; Mayumi,Kamada ^[5] ; Yohei,Harada ^[1] ; Yoshihisa,Tanaka ^[1] ; Mai Adachi,Nakazawa ^[6] ; Yoshinori,Tamada ^[6] ; Yasushi,Okuno ^[6] ; Kenji,Kawada ^[7] ; Kazutaka,Obama ^[8] ; Robert J,Coffey ^[6] ; Yoshiyuki,Fujiwara ^[9] ; Masahiro,Inoue ^[9]

作者单位： Department of Clinical Bioresource Research and Development, Kyoto University Graduate School of Medicine, Kyoto, Japan. ^[1] Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Tottori, Japan. ^[2] Department of Biochemistry, Osaka International Cancer Institute, Osaka, Japan. ^[3] Department of Molecular Biochemistry and Clinical Investigation, Division of Health Science, Osaka University Graduate School of Medicine, Osaka, Japan. ^[4] Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[5] Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan. ^[6] Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. ^[7] RIKEN Center for Computational Science(R-CCS)HPC/HPC- and AI-driven Drug Development Platform Division, Kobe, Japan. ^[8] Department of Medical Data Intelligence and Data Analysis Division, Innovation Center for Health Promotion, Hirosaki University, Hirosaki, Japan. ^[9] Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[10]

关键词 BMP EGFR LRIG1 colorectal cancer organoid

主题词人类(Humans);减量调节(Down-Regulation);骨形态发生蛋白质类(Bone Morphogenetic Proteins);结直肠肿瘤(Colorectal Neoplasms);丝裂原激活蛋白激酶激酶类(Mitogen-Activated Protein Kinase Kinases);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1111/cas.15882

PMID 37357017

发布时间 2024-03-20

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准确一般字义偏差语意偏离译文作用小提交