Design of the elusive proteinaceous oxygen donor copper site suggests a promising future for copper for MRI contrast agents.

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作者： Anokhi,Shah ^[1] ; Michael J,Taylor ^[2] ; Giulia,Molinaro ^[1] ; Sellamuthu,Anbu ^[3] ; Margaux,Verdu ^[3] ; Lucy,Jennings ^[3] ; Iuliia,Mikulska ^[3] ; Sofia,Diaz-Moreno ^[4] ; Hassane,El Mkami ^[4] ; Graham M,Smith ^[1] ; Melanie M,Britton ^[1] ; Janet E,Lovett ^[3] ; Anna F A,Peacock ^[1]

作者单位： Scottish Universities Physics Alliance School of Physics and Astronomy, University of St Andrews, St Andrews KY16 9SS, United Kingdom. ^[1] Biomedical Sciences Research Complex, University of St Andrews, St Andrews KY16 9ST, United Kingdom. ^[2] School of Chemistry, University of Birmingham, Edgbaston B15 2TT, United Kingdom. ^[3] Diamond Light Source, Harwell Science and Innovation Campus, OX11 0DE, Didcot, United Kingdom. ^[4]

关键词 MRI bioinorganic chemistry coiled coil contrast agents protein design

主题词铜(Copper);造影剂(Contrast Media);磁共振成像(Magnetic Resonance Imaging);结合部位(Binding Sites);肽类(Peptides)

DOI 10.1073/pnas.2219036120

PMID 37364102

发布时间 2023-07-06

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准确一般字义偏差语意偏离译文作用小提交