Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome.

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第一作者： Giovanna,Nasilli

第一单位： Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam, The Netherlands.

作者： Giovanna,Nasilli ^[1] ; Loukia,Yiangou ^[2] ; Chiara,Palandri ^[3] ; Elisabetta,Cerbai ^[3] ; Richard P,Davis ^[4] ; Arie O,Verkerk ^[5] ; Simona,Casini ^[1] ; Carol Ann,Remme ^[1]

作者单位： Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam, The Netherlands. ^[1] Department of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. ^[2] Department NeuroFarBa, University of Florence, Viale Gaetano Pieraccini 6, 50139, Florence, Italy. ^[3] Department of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.;The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Albinusdreef 2, 2300 RC, Leiden, The Netherlands. ^[4] Department of Experimental Cardiology, Amsterdam University Medical Center, University of Amsterdam, Heart Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.;Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam, The Netherlands.;Department of Medical Biology, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. ^[5]

关键词 SCN5A Cardiac electrophysiology Ion channels Sudden cardiac death Therapy

主题词人类(Humans);美西律(Mexiletine);QT延长综合征(Long QT Syndrome);Brugada综合征(Brugada Syndrome);动作电位(Action Potentials);肌细胞, 心脏(Myocytes, Cardiac)

DOI 10.1093/europace/euad154

PMID 37369559

发布时间 2023-08-22

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