首页> Cell reports> Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response.

Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response.

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第一作者： Tijana,Randic

第一单位： Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg.

作者： Tijana,Randic ^[1] ; Stefano,Magni ^[2] ; Demetra,Philippidou ^[1] ; Christiane,Margue ^[1] ; Kamil,Grzyb ^[2] ; Jasmin Renate,Preis ^[1] ; Joanna Patrycja,Wroblewska ^[1] ; Petr V,Nazarov ^[3] ; Michel,Mittelbronn ^[4] ; Katrin B M,Frauenknecht ^[5] ; Alexander,Skupin ^[6] ; Stephanie,Kreis ^[7]

作者单位： Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg. ^[1] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg. ^[2] Data Integration and Analysis Unit (DIA), Luxembourg Institute of Health, 1A-B, Rue Thomas Edison, 1445 Strassen, Luxembourg; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, 6A, Rue Nicolas-Ernest Barblé, 1210 Luxembourg, Luxembourg. ^[3] Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, 6A, Rue Nicolas-Ernest Barblé, 1210 Luxembourg, Luxembourg; National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg. ^[4] National Center of Pathology (NCP), Laboratoire National de Santé (LNS), 3555 Dudelange, Luxembourg; Luxembourg Center of Neuropathology (LCNP), Dudelange, Luxembourg. ^[5] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg; Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH), Luxembourg, 6A, Rue Nicolas-Ernest Barblé, 1210 Luxembourg, Luxembourg; Department of Neuroscience, University of California San Diego, 9500 Gillman Drive, La Jolla, CA 92093, USA. ^[6] Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg. Electronic address: stephanie.kreis@uni.lu. ^[7]

关键词 CP: Cancer MEK/CDK4/6 co-inhibition NRAS-mutant melanoma P2RX7 drug resistance single-cell RNA-sequencing