首页> Cell reports> Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

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第一作者： Jinjin,Xu

第一单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

作者： Jinjin,Xu ^[1] ; Lingjia,Kong ^[1] ; Blayne A,Oliver ^[2] ; Bihua,Li ^[1] ; Elizabeth A,Creasey ^[1] ; Gaelen,Guzman ^[3] ; Monica,Schenone ^[3] ; Kimberly L,Carey ^[3] ; Steven A,Carr ^[3] ; Daniel B,Graham ^[1] ; Jacques,Deguine ^[3] ; Ramnik J,Xavier ^[4]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[1] Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[3] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu. ^[4]

关键词 CP: Immunology RNF128 TBK1 signaling autophagy glutamine metabolism glutathione metabolism infection inflammation macrophages proteogenomics