Validation of a method for itraconazole and major metabolite hydroxyitraconazole for LC-MS/MS analysis with application in a formulation clinical study.

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作者： Samuel A,Krug ^[1] ; Ana Luisa,Coutinho ^[1] ; James E,Polli ^[1] ; Maureen A,Kane ^[2]

作者单位： University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA. ^[1] University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA. Electronic address: mkane@rx.umaryland.edu. ^[2]

关键词 Clinical trial Incurred Sample Reanalysis (ISR)Itraconazole Liquid chromatography tandem mass spectrometry (LC-MS/MS)Poorly soluble

主题词人类(Humans);伊曲康唑(Itraconazole);色谱法, 液相(Chromatography, Liquid);串联质谱法(Tandem Mass Spectrometry);结果可重复性(Reproducibility of Results)

DOI 10.1016/j.jpba.2023.115505

PMID 37393691

发布时间 2024-09-21

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