Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues.

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第一作者： Annet N,Linders

第一单位： Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

作者： Annet N,Linders ^[1] ; Itamar B,Dias ^[1] ; Ekaterina S,Ovchinnikova ^[1] ; Mathilde C S C,Vermeer ^[1] ; Martijn F,Hoes ^[2] ; George,Markousis Mavrogenis ^[3] ; Frederik E,Deiman ^[4] ; Karla F,Arevalo Gomez ^[1] ; Jacqueline M,Bliley ^[1] ; Jamil,Nehme ^[1] ; Aryan,Vink ^[5] ; Jourik,Gietema ^[6] ; Rudolf A,de Boer ^[7] ; Daan,Westenbrink ^[8] ; Herman H W,Sillje ^[1] ; Denise,Hilfiker-Kleiner ^[1] ; Linda W,van Laake ^[1] ; Adam W,Feinberg ^[9] ; Marco,Demaria ^[10] ; Nils,Bomer ^[5] ; Peter,van der Meer ^[6]

作者单位： Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. ^[1] Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, the Netherlands. ^[2] CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands. ^[3] Department of Cardiology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands. ^[4] Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania. ^[5] European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. ^[6] Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. ^[7] Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. ^[8] Institute of Cardiovascular Complications in Pregnancy and in Oncologic Therapies, Philipps-Universität Marburg, Marburg, Germany. ^[9] Division of Heart and Lungs and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, the Netherlands. ^[10]

关键词 cardiotoxicity doxorubicin hPSC-derived cardiomyocytes senescence senomorphic drugs

DOI 10.1016/j.jaccao.2023.03.012

PMID 37397084

发布时间 2023-07-04

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JACC. CardioOncology

2023年5卷3期

298-315页

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Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues.

JACC. CardioOncology

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Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues.

JACC. CardioOncology

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JACC. CardioOncology

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