Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.

导出 OA

翻译打印收藏纠错

作者： Kevin R,Zhang ^[1] ; Connor S R,Jankowski ^[2] ; Rayna,Marshall ^[3] ; Rohini,Nair ^[1] ; Néstor,Más Gómez ^[1] ; Ahab,Alnemri ^[1] ; Yingrui,Liu ^[4] ; Elizabeth,Erler ^[1] ; Julia,Ferrante ^[1] ; Ying,Song ^[1] ; Brent A,Bell ^[1] ; Bailey H,Baumann ^[1] ; Jacob,Sterling ^[1] ; Brandon,Anderson ^[1] ; Sierra,Foshe ^[1] ; Jennifer,Roof ^[1] ; Hossein,Fazelinia ^[1] ; Lynn A,Spruce ^[5] ; Jen-Zen,Chuang ^[5] ; Ching-Hwa,Sung ^[5] ; Anuradha,Dhingra ^[6] ; Kathleen,Boesze-Battaglia ^[7] ; Venkata R M,Chavali ^[6] ; Joshua D,Rabinowitz ^[7] ; Claire H,Mitchell ^[4] ; Joshua L,Dunaief ^[4]

作者单位： F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. ^[1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. ^[2] Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. ^[3] Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[4] CHOP-PENN Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. ^[5] Department of Ophthalmology, Weill Cornell Medicine, New York, NY 10065, USA. ^[6] Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA. ^[7]

关键词 Age-related macular degeneration Aging Lysosome Oxidative stress Retina