Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.

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作者： Han Ping,Loh ^[1] ; Farouq Bin,Mahfut ^[1] ; Serene W,Chen ^[1] ; Yuhan,Huang ^[2] ; Jianxin,Huo ^[2] ; Wei,Zhang ^[1] ; Kong Peng,Lam ^[2] ; Shengli,Xu ^[3] ; Yuansheng,Yang ^[2]

作者单位： Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ^[1] Singapore Immunology Network (SIGN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ^[2] Microbiology and Immunology, Singapore, Singapore. ^[3] Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ^[4]

关键词 CHO cell avidity bispecific antibody functionality manufacturability targeted integration thermal stability

主题词抗体, 双特异性(Antibodies, Bispecific);T淋巴细胞(T-Lymphocytes);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);免疫球蛋白G(Immunoglobulin G);单链抗体(Single-Chain Antibodies)

DOI 10.1080/19420862.2023.2231129

PMID 37403264

发布时间 2023-07-18

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Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.

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Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.

mAbs

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mAbs

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