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Proliferative activity of antigen-specific CD154+ T cells against bacterial and fungal respiratory pathogens in cystic fibrosis decreases after initiation of highly effective CFTR modulator therapy.

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第一作者： Patience N,Eschenhagen

第一单位： Cystic Fibrosis Section, Klinikum Westbrandenburg, Campus Potsdam, Potsdam, Germany.;HMU Health and Medical University, Potsdam, Germany.;Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

作者： Patience N,Eschenhagen ^[1] ; Petra,Bacher ^[2] ; Claudia,Grehn ^[3] ; Jochen G,Mainz ^[4] ; Alexander,Scheffold ^[5] ; Carsten,Schwarz ^[1]

作者单位： Cystic Fibrosis Section, Klinikum Westbrandenburg, Campus Potsdam, Potsdam, Germany.;HMU Health and Medical University, Potsdam, Germany.;Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany. ^[1] Institute of Clinical Molecular Biology, Christian-Albrecht-University of Kiel, Kiel, Germany.;Institute of Immunology, Christian-Albrecht-University of Kiel and UKSH Schleswig-Holstein, Kiel, Germany. ^[2] Berlin Institute of Health at Charité Universitätsmedizin, Berlin, Germany. ^[3] Cystic Fibrosis Center, Brandenburg Medical School (MHB) University, Brandenburg, Germany.;Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, The Brandenburg Medical School Theodor Fontane and the University of Potsdam, Potsdam, Germany. ^[4] Institute of Clinical Molecular Biology, Christian-Albrecht-University of Kiel, Kiel, Germany. ^[5]

关键词 Aspergillus fumigatus Ki-67 Pseudomonas aeruginosa antigen-specific T cells cystic fibrosis highly effective modulator therapy total IgE total IgG

DOI 10.3389/fphar.2023.1180826

PMID 37408761

发布时间 2023-07-18

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