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Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart.

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第一作者： Xisheng,Li

第一单位： Cardiovascular Research Institute (X.L., S.L.S., M.A., E.C., D.C., E.L.-G., S.Y., N.A., D.J., S.L., A.P., N.R., S.Z., L.Z., S.S.), Icahn School of Medicine at Mount Sinai, New York, NY.

作者： Xisheng,Li ^[1] ; Sabrina,La Salvia ^[1] ; Yaxuan,Liang ^[2] ; Marta,Adamiak ^[1] ; Erik,Kohlbrenner ^[3] ; Dongtak,Jeong ^[4] ; Elena,Chepurko ^[1] ; Delaine,Ceholski ^[1] ; Estrella,Lopez-Gordo ^[1] ; Seonghun,Yoon ^[1] ; Prabhu,Mathiyalagan ^[5] ; Neha,Agarwal ^[1] ; Divya,Jha ^[1] ; Shweta,Lodha ^[1] ; George,Daaboul ^[6] ; Anh,Phan ^[1] ; Nikhil,Raisinghani ^[1] ; Shihong,Zhang ^[1] ; Lior,Zangi ^[1] ; Edgar,Gonzalez-Kozlova ^[7] ; Nicole,Dubois ^[8] ; Navneet,Dogra ^[9] ; Roger J,Hajjar ^[10] ; Susmita,Sahoo ^[1]

作者单位： Cardiovascular Research Institute (X.L., S.L.S., M.A., E.C., D.C., E.L.-G., S.Y., N.A., D.J., S.L., A.P., N.R., S.Z., L.Z., S.S.), Icahn School of Medicine at Mount Sinai, New York, NY. ^[1] Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai, China (Y.L.). ^[2] Cardiovascular Research Institute (X.L., S.L.S., M.A., E.C., D.C., E.L.-G., S.Y., N.A., D.J., S.L., A.P., N.R., S.Z., L.Z., S.S.), Icahn School of Medicine at Mount Sinai, New York, NY.;Spark Therapeutics, Philadelphia, PA (E.K.). ^[3] Department of Molecular and Life Science, College of Science and Convergence Technology, Hanyang University-ERICA, Ansan, South Korea (D.J.). ^[4] Benthos Prime Central, Houston, TX (P.M.). ^[5] NanoView Biosciences, Boston, MA (G.D.). ^[6] Department of Oncological Sciences (E.G.-K.), Icahn School of Medicine at Mount Sinai, New York, NY. ^[7] Department of Cell, Developmental and Regenerative Biology (N. Dubois), Icahn School of Medicine at Mount Sinai, New York, NY.;Mindich Child Health and Development Institute (N. Dubois), Icahn School of Medicine at Mount Sinai, New York, NY. ^[8] Department of Pathology and Laboratory Medicine (N. Dogra), Icahn School of Medicine at Mount Sinai, New York, NY.;Icahn Genomics Institute (N.Dogra), Icahn School of Medicine at Mount Sinai, New York, NY. ^[9] Gene and Cell Therapy Institute, Massachusetts General Brigham, Boston (R.J.H.). ^[10]

关键词 extracellular vesicles genetic therapy

医学主题词人类(Humans);小鼠(Mice);动物(Animals);依赖病毒(Dependovirus);肌浆网钙转运ATP酶类(Sarcoplasmic Reticulum Calcium-Transporting ATPases);遗传载体(Genetic Vectors);诱导多能干细胞(Induced Pluripotent Stem Cells);抗体, 中和(Antibodies, Neutralizing)

DOI 10.1161/CIRCULATIONAHA.122.063759

PMID 37409482

发布时间 2025-09-26

基金项目

R01 DK125856/DK/NIDDK NIH HHS/United States R01 HL124187/HL/NHLBI NIH HHS/United States R01 HL140469/HL/NHLBI NIH HHS/United States R01 HL148786/HL/NHLBI NIH HHS/United States

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