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首页> Bioorganic & medicinal chemistry> Discovery of novel hybrids of mTOR inhibitor and NO donor as potential anti-tumor therapeutics.

Discovery of novel hybrids of mTOR inhibitor and NO donor as potential anti-tumor therapeutics.

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第一作者： Xin,Gao

第一单位： School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.

作者： Xin,Gao ^[1] ; Fang,Zhao ^[1] ; Yang,Wang ^[2] ; Xiaodong,Ma ^[2] ; Huayi,Chai ^[1] ; Jingjing,Han ^[1] ; Fang,Fang ^[3]

作者单位： School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. ^[1] School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China. ^[2] School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China. Electronic address: ffahtcm@126.com. ^[3]

关键词 Anti-proliferative MLN0128 NO donor Structure-activity relationship mTOR inhibitors

主题词人类(Humans);抗肿瘤药(Antineoplastic Agents);一氧化氮供体(Nitric Oxide Donors);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);肿瘤(Neoplasms);细胞增殖(Cell Proliferation);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);细胞系, 肿瘤(Cell Line, Tumor);药物设计(Drug Design);构效关系(Structure-Activity Relationship);蛋白激酶抑制剂(Protein Kinase Inhibitors);分子结构(Molecular Structure)

DOI 10.1016/j.bmc.2023.117402

PMID 37421709

发布时间 2023-08-01

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