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首页> The Journal of biological chemistry> Simultaneous isolation of hormone receptor-positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms.

Simultaneous isolation of hormone receptor-positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms.

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作者： Jenny M,Hogstrom ^[1] ; Kayla A,Cruz ^[1] ; Laura M,Selfors ^[2] ; Madelyn N,Ward ^[1] ; Tejas S,Mehta ^[3] ; Naama,Kanarek ^[4] ; Jordana,Philips ^[3] ; Vandana,Dialani ^[3] ; Gerburg,Wulf ^[1] ; Laura C,Collins ^[5] ; Jaymin M,Patel ^[1] ; Taru,Muranen ^[6]

作者单位： Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. ^[1] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. ^[2] Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. ^[3] Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[4] Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. ^[5] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: tmuranen@bidmc.harvard.edu. ^[6]

关键词 CAF CCL19 GROα PDO cancer-associated fibroblast chemokine co-culture model cytokine drug resistance estrogen receptor fulvestrant hormone receptor–positive breast cancer luminal breast cancer patient-derived organoids tumor-stroma cross talk

主题词人类(Humans);女(雌)性(Female);乳腺肿瘤(Breast Neoplasms);受体, 雌激素(Receptors, Estrogen);肿瘤复发, 局部(Neoplasm Recurrence, Local);成纤维细胞(Fibroblasts);类器官(Organoids);肿瘤微环境(Tumor Microenvironment)

DOI 10.1016/j.jbc.2023.105021

PMID 37423299

发布时间 2023-09-06

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The Journal of biological chemistry

The Journal of biological chemistry

2023年299卷8期

105021页

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