Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models.

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第一作者： Qiuxue,Han

第一单位： Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China.

作者： Qiuxue,Han ^[1] ; Shen,Wang ^[2] ; Zhenshan,Wang ^[2] ; Cheng,Zhang ^[2] ; Xinyue,Wang ^[2] ; Na,Feng ^[2] ; Tiecheng,Wang ^[2] ; Yongkun,Zhao ^[3] ; Hang,Chi ^[4] ; Feihu,Yan ^[5] ; Xianzhu,Xia ^[6]

作者单位： Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China. ^[1] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China. ^[2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China; Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China. ^[3] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China. Electronic address: ch_amms@163.com. ^[4] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China; Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China. Electronic address: yanfh1990@163.com. ^[5] Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 132122, China; Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China. Electronic address: xiaxzh@cae.cn. ^[6]

关键词 Broad-spectrum COVID-19 Nanobody Rodent models SARS-CoV-2 Therapeutic

主题词仓鼠亚科(Cricetinae);人类(Humans);动物(Animals);小鼠(Mice);骆驼, 新大陆(Camelids, New World);疾病模型, 动物(Disease Models, Animal);免疫球蛋白G(Immunoglobulin G);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral)

DOI 10.1016/j.virs.2023.07.003

PMID 37423308

发布时间 2023-11-03

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Virologica Sinica

2023年38卷5期

787-800页

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Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models.

Virologica Sinica

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Virologica Sinica

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Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models.

Virologica Sinica

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Virologica Sinica

相关期刊

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