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Predicting self-diffusion coefficients in semi-crystalline and amorphous solid dispersions using free volume theory.

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第一作者： Ali,Mansuri

第一单位： TU Dortmund University, Department of Biochemical and Chemical Engineering, 44227 Dortmund, Germany; INVITE GmbH, 51061 Cologne, Germany.

作者： Ali,Mansuri ^[1] ; Milan,Völkel ^[2] ; Dilshan,Mihiranga ^[2] ; Tim,Feuerbach ^[3] ; Judith,Winck ^[2] ; Arnoldus W P,Vermeer ^[4] ; Werner,Hoheisel ^[3] ; Markus,Thommes ^[5]

作者单位： TU Dortmund University, Department of Biochemical and Chemical Engineering, 44227 Dortmund, Germany; INVITE GmbH, 51061 Cologne, Germany. ^[1] TU Dortmund University, Department of Biochemical and Chemical Engineering, 44227 Dortmund, Germany. ^[2] INVITE GmbH, 51061 Cologne, Germany. ^[3] Bayer AG, 40789 Monheim am Rhein, Germany. ^[4] TU Dortmund University, Department of Biochemical and Chemical Engineering, 44227 Dortmund, Germany. Electronic address: professors.fsv.bci@tu-dortmund.de. ^[5]

关键词 Amorphous polymers Diffusion Drug diffusion coefficient Fragility Free volume theory Molecular mobility Semi-crystalline polymers Solid dispersions

医学主题词聚维酮(Povidone);化学, 药物(Chemistry, Pharmaceutical);溶解度(Solubility);聚合物(Polymers)

DOI 10.1016/j.ejpb.2023.07.001

PMID 37423417

发布时间 2023-08-28

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