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In vitro dissolution/permeation tools for amorphous solid dispersions bioavailability forecasting I: Experimental design for PermeaLoop™.

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第一作者： Patrícia D,Nunes

第一单位： R&D Analytical Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal; R&D Oral Drug Product Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal; Research Institute for Medicines (iMed.Ulisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.

作者： Patrícia D,Nunes ^[1] ; João F,Pinto ^[2] ; Annette,Bauer-Brandl ^[3] ; Martin,Brandl ^[4] ; João,Henriques ^[5] ; Ana Mafalda,Paiva ^[6]

作者单位： R&D Analytical Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal; R&D Oral Drug Product Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal; Research Institute for Medicines (iMed.Ulisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. ^[1] Research Institute for Medicines (iMed.Ulisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. Electronic address: jfpinto@ff.ulisboa.pt. ^[2] Drug Transport and Delivery Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense DK, 5230, Denmark. ^[3] Drug Transport and Delivery Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense DK, 5230, Denmark. Electronic address: mmb@sdu.dk. ^[4] R&D Oral Drug Product Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal. ^[5] R&D Analytical Development, Hovione Farmaciência S.A., Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal. ^[6]

关键词 Absorption forecasting Biomimetic in vitro methods Dissolution/permeation Enabling formulations PermeaLoop?Structured method development

医学主题词溶解度(Solubility);生物利用度(Biological Availability);化学, 药物(Chemistry, Pharmaceutical);研究设计(Research Design);伊曲康唑(Itraconazole)

DOI 10.1016/j.ejps.2023.106512

PMID 37423576

发布时间 2023-08-15

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