An Aptamer-Functionalized DNA Circuit to Establish an Artificial Interaction between T Cells and Cancer Cells.

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第一作者： Zhimin,Wang

第一单位： Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

作者： Zhimin,Wang ^[1] ; Yue,Zhang ^[1] ; Limei,Wu ^[1] ; Jianghuai,Chen ^[1] ; Sitao,Xie ^[2] ; Jiaxuan,He ^[2] ; Qiang,Zhang ^[1] ; Hong,Chen ^[1] ; Fengming,Chen ^[1] ; Yue,Liu ^[1] ; Yutong,Zhang ^[1] ; Yuting,Zhuo ^[1] ; Nachuan,Wen ^[1] ; Liping,Qiu ^[1] ; Weihong,Tan ^[2]

作者单位： Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China. ^[1] The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. ^[2] Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. ^[3]

关键词 Aptamers Cell-Cell Interaction DNA Circuit Receptors T Cell Immunity

主题词 T淋巴细胞(T-Lymphocytes);适体, 核苷(Aptamers, Nucleotide);DNA(DNA);细胞膜(Cell Membrane);免疫疗法(Immunotherapy);肿瘤(Neoplasms)

DOI 10.1002/anie.202307656

PMID 37423897

发布时间 2023-10-13

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