Limited clinical activity of palbociclib and ribociclib monotherapy in advanced cancers with cyclin D-CDK4/6 pathway alterations in the Dutch DRUP and Australian MoST trials.

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第一作者： Laurien J,Zeverijn

第一单位： Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

作者： Laurien J,Zeverijn ^[1] ; Eleonora J,Looze ^[2] ; Subotheni,Thavaneswaran ^[3] ; J Maxime,van Berge Henegouwen ^[4] ; Robert J,Simes ^[5] ; Louisa R,Hoes ^[6] ; Katrin M,Sjoquist ^[2] ; Hanneke,van der Wijngaart ^[7] ; Lucille,Sebastian ^[6] ; Birgit S,Geurts ^[1] ; Chee K,Lee ^[2] ; Gijsbrecht F,de Wit ^[6] ; David,Espinoza ^[2] ; Paul,Roepman ^[8] ; Frank P,Lin ^[6] ; Anne M L,Jansen ^[1] ; Wendy W J,de Leng ^[2] ; Vincent,van der Noort ^[6] ; Lindsay V M,Leek ^[1] ; Filip Y F L,de Vos ^[2] ; Carla M L,van Herpen ^[6] ; Hans,Gelderblom ^[9] ; Henk M W,Verheul ^[4] ; David M,Thomas ^[5] ; Emile E,Voest ^[6]

作者单位： Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[1] Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[2] Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. ^[3] The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia. ^[4] St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia. ^[5] NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia. ^[6] Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. ^[7] Department of Medical Oncology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands. ^[8] Hartwig Medical Foundation, Amsterdam, The Netherlands. ^[9] Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[10] Biometrics Department, Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[11] Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[12] Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[13] Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. ^[14] Department of Medical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands. ^[15] Center for Personalized Cancer Treatment, Rotterdam, The Netherlands. ^[16]

关键词 CDK4/6 inhibitors drug rediscovery monotherapy precision oncology targeted therapy