A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclic <i>N</i>-heterocycles.

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作者： Rachel K,Chambers ^[1] ; Jacob D,Weaver ^[1] ; Jinho,Kim ^[1] ; Jason L,Hoar ^[2] ; Shane W,Krska ^[2] ; M Christina,White ^[1]

作者单位： Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL 61801. ^[1] Department of Discovery Chemistry, Merck & Co., Inc., Rahway, NJ 07065. ^[2]

关键词 CYP450 mimic C–H activation bioisosteres metabolism oxidation

主题词氧化还原(Oxidation-Reduction);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);肝(Liver);药用制剂(Pharmaceutical Preparations);催化作用(Catalysis);微粒体, 肝(Microsomes, Liver);氮(Nitrogen)

DOI 10.1073/pnas.2300315120

PMID 37428920

发布时间 2024-02-10

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Proceedings of the National Academy of Sciences of the United States of America

2023年120卷29期

e2300315120页

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A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclic <i>N</i>-heterocycles.

Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

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A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclic <i>N</i>-heterocycles.

Proceedings of the National Academy of Sciences of the United States of America

相似文献

Proceedings of the National Academy of Sciences of the United States of America

相关期刊

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